Serving up spondyloarthritis: time for a clinical hawkeye
Spondyloarthritis is an uncommon collection of chronic inflammatory systemic disorders. Athletic populations may be at greater risk of misdiagnosis due to the physical demands of sport and the high prevalence of back pain during peak training or competition periods. Chris Mallac explores spondyloarthritis and provides a management outline for clinicians.

WTA 250 – Upper Austria Ladies Linz – Britain’s Emma Raducanu receives medical attention during her round of 16 match against China’s Wang Xinyu REUTERS/Leonhard Foeger
Spondyloarthritis (SpA) is an uncommon collection of chronic inflammatory systemic disorders. Pain may present insidiously in the spine and refer to the buttock region. Axial SpA (ax-SpA) is the most common of these conditions and affects the spine and sacroiliac joints. The most common form of ax-SpA is Ankylosing Spondylitis (AS), known as radiographic axial SpA (r-axSpA). Radiological ax-SpA shows structural changes on imaging instead of non-radiographic axial SpA (non-r-axSpA), which does not but presents with similar signs and symptoms(1).
Other forms of SpA may present in clinical sports medicine, and clinicians need to maintain a high level of suspicion when assessing athletes with ongoing inflammatory signs or symptoms(1,2). These include:
- Psoriatic arthritis (PsA)
- Inflammatory bowel disease (IBD) associated arthritis
- Reactive arthritis (also known as Reiter’s Syndrome) (ReA)
- Undifferentiated SpA
- Peripheral SpA
- Juvenile onset SpA.
Although the prevalence of SpA is quite rare, sports medicine professionals need to understand the pathophysiology as it coincides with other soft tissue disorders involving the enthesis, particularly at the Achilles tendon insertion, plantar fascia, and patella tendon.
Clinical Presentation
Spondyloarthritis presents with varying severity and may be challenging to identify in the early disease stages. However, there are key clinical features of SpA, which include(1,3,4):
- Vague daily buttock pain in the early stages.
- Early morning stiffness > one hour.
- Pain and stiffness in other spinal regions.
- Symptoms improve with NSAID’s and movement while aggravated by rest.
- Up to 30% of patients have enthesis issues in the Achilles, plantar fascia, or patella tendon and dactylitis (sausage digit) which is usually asymmetrical.
- Extra-musculoskeletal manifestations (EMM) such as uveitis (25% of patients), psoriasis (10%), or inflammatory bowel disease, which includes ulcerative colitis and Crohn’s disease (5-10%).
Epidemiology
The presentation of ax-SpA usually starts in the late twenties and into the thirties. It is rare for it to manifest after the age of 45. It is more common for males to have r-axSpA at a ratio of 2:1 with an equal ratio of 1:1 for non-r-ax-SpA(5). Estimating the worldwide prevalence is challenging, but r-axSpA is between 0.1-1.4%, with the overall SpA prevalence between 0.5-1.9%(1,6). Notably, the presence of the HLA-B27 gene increases the risk of developing the disease(1,6). This gene is more common in Northern European, circumpolar arctic, and subarctic populations of North America and Eurasia and rare in southern African and Japanese populations(7).
________________________________________________________________________________________
The association between HLA-B27 and SpA(6,8,9,10)
- HLA-B27 and AS – up to 90%
- HLA-B27 and ReA – reports of 50 to 60 to 85%
- HLA-B27 and Undifferentiated SpA – 50%
- HLA-B27 and Juvenile Onset SpA – 60-80%.
________________________________________________________________________________________
Pathophysiology
A genetic predisposition plays a significant role in the manifestation of ax-SpA. The primary genes identified are HLA-B27, endoplasmic reticulum aminopeptidase (ERAP), and the interleukin-23 receptor (IL_23)(11). The primary affected structure in axSpA is the enthesis and subchondral bone, with pathology developing at these sites over time.
The mechanical and chemical triggers activate inflammation at the enthesis, and subchondral bone changes occur. These changes manifest as a fluctuation between bone destruction and formation(3,12). Pro-inflammatory cytokines such as tumor necrosis factor and IL-23/IL-17 may induce bone destruction, while bone morphogenic proteins and Wnt proteins promote repair. Radiological investigations reveal structural bone changes such as bone marrow edema on MRI and erosion, sclerosis, and new bone formation on X-ray. Clinically, the patient will present with inflammatory signs such as pain and stiffness, progressing to inflammation at the enthesis of other joints (Achilles and plantar fascia), joint arthritis, dactylitis (inflammation of the synovium and tendons of the digits), and other EEM’s.
Diagnostics
Blood Tests
The HLA-B27 gene is present in 70-90% of SpA cases. Furthermore, blood samples may demonstrate elevated levels of c-reactive protein (CRP) and erythrocyte sedimentation rate (ESR); however, 60% of patients with symptoms of axial SpA show normal CRP and ESR levels initially(13).
Imaging
In the early stages of SpA, MRI is the gold standard for identifying disease. An MRI of the axial skeleton and sacroiliac joints demonstrates bone marrow edema, representing inflammation(14). In advanced cases, plain X-rays show structural defects such as erosion, sclerosis, joint space abnormalities, and possible ankylosis. In addition, in severe cases, plain X-rays may show extreme bone changes in the spine with fusion known as the ‘bamboo’ spine (see figure 1)(15).
Figure 1: X-ray of advanced Ankylosing Spondylitis (Bamboo Spine)

Diagnostic Algorithm
The Assessment in Spondylo-Arthritis International Society (ASAS) provides a diagnostic algorithm to assist clinicians(16). The algorithm considers that a ‘cluster’ of symptoms needs to exist to diagnose axial-SpA as the signs and symptoms vary widely (see table 1). Furthermore, researchers at La Paz University Hospital in Spain created a diagnostic pathway that incorporates imaging findings, blood pathology results, and SpA signs and symptoms to ensure an accurate diagnosis (see figure 2).
Table 1: The typical features of SpA and the associated likelihood ratio.
SpA feature | Likelihood ratio (LR+) |
Psoriasis | 2.5 |
Raised CRP/ESR | 2.5 |
Inflammatory back pain | 3.1 |
Heel enthesis | 3.4 |
Inflammatory Bowel Disease | 4.0 |
Peripheral Arthritis | 4.0 |
Dactylitis | 4.5 |
Good response to NSAID’s | 5.1 |
Positive family history | 6.4 |
Acute anterior uveitis | 7.3 |
HLA-B27 (Clinical arm entry) | 9.0 |
Sacroiliitis on MRI (Imaging arm entry) | 9.0 |
Radiographic sacroiliitis >3 (Imaging arm entry) | 20 |
The higher the LR, the more likely the patient has axial-SpA.
A delay between the start of chronic low back pain and the diagnosis of SpA exists. It can take five to seven years from the onset of chronic low back pain to a SpA diagnosis. This diagnostic delay is more significant in women than men(17). The most likely reason is clinician bias. As the age of onset is typical during an active, busy work-life period, and childbearing years, clinicians may mistake the signs and symptoms for more common causes such as postural issues and general muscular deconditioning due to lifestyle factors. Furthermore, age-related changes that appear on imaging, such as disc degeneration and facet joint hypertrophy, may mislead clinicians when assessing and managing individuals with chronic lower back pain leading to a delay in a SpA diagnosis(18). Athletes may be at greater risk for misdiagnosis, as back pain may be associated with physical activities, particularly sports with high loads.
Figure 2: Flow chart showing a diagnostic pathway for SpA(3)

Management
Spondyloarthritis is a chronic disease has that has its basis as an autoinflammatory condition(19). Therefore, it is not self-limiting but rather a progressive disease. A key component of management is athlete advice and education. A multi-disciplinary team may manage the condition conservatively with exercise and pharmacological treatment.
Physical exercise
Exercise is the cornerstone of conservative management as it may alleviate symptoms, improve function, and develop a sense of control for the athlete(20). As the disease progresses, impact activities, repetitive spinal flexion cardio-vascular training (e.g., rowing ergometer), and heavy load weight training may lead to further inflammation and extra bone formation at the enthesis and articular surfaces under load. Clinicians may advise athletes to limit these activities and provide an alternative to maintain athletic competence and physical well-being.
___________________________________________________________________________________________
Exercise options for SpA individuals
- Swimming and hydrotherapy.
- Pilates and yoga
- Cycling, recumbent cycling, cross trainer, Nordic ski training, and gravity reduced running (Alter-G treadmill)
- Light resistance gym training (circuit type training).
- Breathing exercises may reduce thoracic kyphosis and improve lung expansion in later stages of the disease.
___________________________________________________________________________________________
Pharmacology(3)
There are multiple pharmacological options for clinicians and athletes. The primary aim of pharmacological treatment is to reduce inflammation and manage the autoimmune response. The options available include:
- Non-steroidal anti-inflammatory drugs (NSAIDs) – Athletes should trial NSAIDs over two weeks to assess symptoms response. If one line of NSAIDs does not give relief, clinicians can advise an alternative. Likewise, if athletes do not achieve relief after four weeks, clinicians recommend disease-modifying medications.
- Biological disease-modifying antirheumatic drugs (bDMARD) – There are two bDMARD classes available to individuals. Both classes work well in symptom relief, with TNFi usually the first-line treatment.
- Class 1: TNFi (e.g., etanercept, certolizumab, adalimumab, pegol,
- Class 2: IL-17i (e.g., secukinumab, ixekizumab)
- Traditional medications such as methotrexate and hydroxychloroquine are effective for symptom relief.
- Clinicians may use Sulfasalazine for peripheral arthritis
- Local corticosteroid injections into joints.
Conclusion
Spondyloarthritis is a relatively rare autoimmune inflammatory condition that presents in the late twenties and early thirties. This will most likely not be a limiting factor for the elite athlete until they reach their third decade. However, it may present insidious, chronic low back pain for the aging athlete. It worsens with rest and improves with exercise. In addition, athletes may show extra musculoskeletal manifestations such as Achilles and plantar fascia enthesis issues. Clinicians diagnose SpA through a comprehensive assessment which includes signs and symptoms, imaging, and blood tests. Athletes and clinicians manage spondyloarthritis with education, commitment to exercise, and pharmacological treatment.
References
- Lancet 2017; 390: 73–84
- Curr Opinions Rheumatol. 2005; 17(4): 395-399.
- Ann Rheum Dis. 2021; 80: 1511-1521.
- Arthritis Res Ther. 2016; 18: 196.
- Arthritis Rheum. 2009: 60; 717-27.
- Rheumatol Rep. 2013; 15(9): 351.
- Arthritis Care Res. 2016; 68: 1320-1331.
- Arthritis Care Res. 2013; 65(8): 1299-1306.
- Arthritis Care. 2013. 65(3): 448-453.
- Arthritis Rheum. 2013. 65(1): 12-20.
- Nat Genet. 2013; 45: 730-738.
- Nat Rev Rheumatol. 2017; 13: 731-41.
- J Rheumatology. 1999: 26; 980-984.
- Ann Rheum Dis. 2016:; 75: 1958-1963.
- Bone Research. 2019; 7: 22.
- Ann Rheum Dis. 2013; 72: 1646-53.
- J Rheumatol. 2017; 44: 174-83.
- Joint Bone Spine. 2013; 80: 582-585.
- Curr Opin Rheumatol. 2012; 24: 351-358.
- Best Practice & Research Clinical Rheumatology. 2014; 28: 779-792.
Related
in Diagnose & Treat, Improve, Pre-hab and post-surgical rehab, Prevent, Sports psychology
Experiencing pain is a fundamental biopsychosocial phenomenon. However, practitioners typically treat pain in isolation with little emphasis on psychological influence. Carl Bescoby explores the psychological impact of pain and discusses how psychologically informed practice may offer benefits to managing the whole pain experience throughout rehabilitation. Introduction It is common for athletes to experience pain when... MORE
in Anatomy, Diagnose & Treat, Improve, Prevent, Sports psychology
Researchers obtain qualitative data through first-hand observation, interviews, questionnaires, and other non-numerical sources of information. Jason Tee explores how clinicians can utilize the qualitative data and the athlete’s voice to improve rehabilitation outcomes. Sports injury research is clinical, impartial, and objective. It reduces athlete injuries to numbers and figures, removing the stories of the athletes... MORE
in Acute injuries, Diagnose & Treat, Hip injuries, Knee injuries, Leg injuries, Musculoskeletal injuries, Prevent, Strength, Uncommon injuries
An injury will, directly and indirectly, affect the entire kinetic chain. Therefore, practitioners should develop holistic clinical assessment and rehabilitation plans. Cameron Gill reviews the complex interplay between the hamstring injury and ACL rupture risk to aid clinical judgment and decision making. Over his first eight seasons, NBA sharpshooter Klay Thompson never missed more than... MORE
in Ankle and foot injuries, Diagnose & Treat, Improve, Knee injuries, Pre-hab and post-surgical rehab, Prevent
Artificial playing surfaces are contentious and remain a talking point in Sports and Exercise Medicine. Marianke van der Merwe uncovers the artificial surface injury risk and provides recommendations to mitigate the risk factors for athletes. Artificial turf was first introduced in the 1960s and has evolved significantly. There are three reasons for artificial turf. Firstly,... MORE
in Acute injuries, Diagnose & Treat, Improve, Musculoskeletal injuries, Overuse injuries, Pre-hab and post-surgical rehab, Prevent
Groin pain remains a challenging sports injury to manage. The complex regional anatomy provides practitioners with the unenviable task of diagnosing and managing athletes with groin pain. However, a universal terminology and taxonomy would assist practitioners in diagnosing and managing these athletes through the return to play process. In part I, Candice MacMillan discusses the... MORE
in Acute injuries, Diagnose & Treat, Female Athletes, Other, Pre-hab and post-surgical rehab
Sports-related concussions (SRC) occur in most sports at all levels. However, female athletes experience more concussions and worse outcomes than their male counterparts, yet these gender differences are unknown in clinical practice. Tracy Ward explores the pathophysiology, implications, and management of SRC in female athletes. Sports-related concussion (SRC) management is at the forefront of sports... MORE